Allergy and Allergic Diseases, 2 Volume Set by A. Barry Kay, Jean Bousquet, Patrick G. Holt, Allen P.

By A. Barry Kay, Jean Bousquet, Patrick G. Holt, Allen P. Kaplan

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This quantity booklet is a phenomenal reference resource on all points of hypersensitivity and allergic illnesses. overlaying nearly each allergic situation, from the immunological and molecular foundation of the allergic reaction to destiny tendencies in allergic ailment prevention, this new overseas editorial crew (A.B.Kay, Jean Bousquet, Pat Holt and Allen Kaplan) have thoroughly revised and up-to-date the textual content, from either a systematic and medical point of view. References will remain further to the textual content till it is going to press making this the main updated publication on hand within the field.

This moment version involves greater than 1,800 pages contained inside ninety eight chapters.

The fee encompasses a totally searchable significant other CD ROM with the total textual content and over three hundred pictures from the e-book in complete colour.

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Sample text

Some hypersensitivity reactions do not fall neatly into the type 1–IV classification. For example, activation of the plasma cascade via factor XII, prekallikrein, and high-molecularweight kininogen leads to bradykinin formation, the critical mediator of hereditary angioedema (Fields et al. 1983). Concluding comments The full history of allergy is long and complex and only a relatively superficial account can be given here. The story of direct relevance to atopic allergic disease ranges from the first full description of anaphylaxis in 1903 to the discovery of IgE in the 1960s.

But it was Leonard Noon (1911) (Fig. 25) who successfully introduced specific injection therapy for hay fever. After his premature death from tuberculosis, his colleague John (a) 12 (b) Fig. 21 (a) Jean Martin Charcot (1825–93) and (b) Ernst V. von Leyden (1832–1910). The needle-like (eosinophil-derived) crystals characteristic of asthmatic sputum are named after Charcot and Leyden. qxd 4/1/08 20:04 Page 13 CHAPTER 1 Allergy and Hypersensitivity: History and Concepts Fig. 23 John Bostock (1773–1846).

J Physiol (Lond) 172, 72–3. B. (1953) Mast cells and histamine in normal and pathological tissues. J Physiol 119, 44P. , Beraldo, W. & Rosenfeld, G. (1949) Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and trypsin. Am J Physiol 156, 261–73. Romagnani, S. (2006) Regulation of the T cell response. Clin Exp Allergy 36, 1357–66. S. L. (1965) A new class of human immunoglobulins. I. A unique myeloma protein. J Exp Med 121, 171–99. O. (1936) Histamine release and anaphylactic shock in isolated lungs of guinea pigs.

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