Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

By Kian Fan Chung

During this booklet, prime researchers in medication and molecular pharmacology clarify the mobile mechanisms that keep an eye on airway tender muscle. The potential during which those are disrupted in ailment, and the pharmacologic options through which they're changed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the freshest details on one of many middle physiological methods in airway ailment, and gives insights into present and destiny ways to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most modern learn to bronchodilator therapyMulti-contributed textual content, co-coordinated via of the major gurus within the box.

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J Appl Physiol 89, 869–876. , Gunst, S. J. and Tepper, R. S. (1997). Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J Appl Physiol 83, 1202– 1208. Shore, S. , Hall, I. et al. (1997). Effect of IL-1␤ on responses of cultured human airway smooth muscle cells to bronchodilator agonists. Am J Respir Cell Mol Biol 16, 702–712. Silveira, P. S. P. and Fredberg, J. J. (2005). Smooth muscle length adaptation and actin filament length: a network model of the cytoskeletal dysregulation.

Tyska, M. , Rovner, A. S. et al. (1998). A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap. J Muscle Res Cell Motil 19, 825–837. Lazaar, A. L. and Panettieri, R. A. (2005). Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy Clin Immunol 116, 488–495. Leckie, M. , ten Brinke, A. and Khan, J, (2000). Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

J Appl Physiol 70, 1044–1050. Salter, H. H. (1868). On Asthma: Its Pathology and Treatment, pp. 24-60. John Churchill & Sons, Science Press Limited: London. PIC OTE/SPH JWBK153-01 March 28, 2008 28 19:0 Char Count= 0 CH 1 BIOPHYSICAL BASIS OF AIRWAY SMOOTH MUSCLE CONTRACTION Seow, C. Y. and Fredberg, J. J. (2001). Historical perspective on airway smooth muscle: the saga of a frustrated cell. J Appl Physiol 91, 938–952. Seow, C. Y. and Stephens, N. L. (1988). Velocity–length–time relations in canine tracheal smooth muscle.

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