By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This booklet is the 6th quantity within the sequence Acute publicity guide degrees for Selected Airborne Chemicals, and contains AEGLs for chemical substances resembling ammonia, nickel carbonyl and phosphine, between others.
At the request of the dep. of safeguard, the nationwide learn Council has reviewed the correct medical literature compiled via a professional panel and confirmed Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs characterize publicity degrees under which opposed future health results aren't more likely to happen and are precious in responding to emergencies similar to unintentional or intentional chemical releases locally, the office, transportation, the army, and for the remediation of infected sites.
Three AEGLs are authorized for every chemical, representing publicity degrees that lead to: 1) extraordinary yet reversible pain; 2) long-lasting future health results; and three) life-threatening overall healthiness impacts.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
2001; Boor and Hysmith 1987; Lyles 1996). SSAO specificity for allylamine as a substrate has not been determined, and Lyles (1996) has shown that substrate specificity of plasma and tissue SSAO varied considerably among species for a number of aromatic and aliphatic amines. Inhalation exposure was also capable of inducing cardiovascular lesions, although this was shown only in rats. The data thus suggest that a similar mechanism is responsible for cardiovascular injury in many Copyright © National Academy of Sciences.
1961 EKG changes. As for 10 days but more severe; “healing” seen in some areas. Fragmentation of muscle bundles, edematous arterioles (non-acute). 4 h/day for 73 days (5 day/week) No detectable (gross or microscopic) heart lesions Guzman et al. 1961 6 h/day for 414 days No histologic changes in nose, trachea, lungs Zissu 1995 the animals died prematurely, and there were no gross or microscopic heart lesions, alterations in heart/body-weight ratios, or changes in EKGs after the 73 exposures. 2. Rats Guzman et al.
Those exposed briefly to 14 ppm reported it to be intolerable. , slight headache and nausea) were reported but were not dose related. 6 ppm; Shell Oil Co. 1992). Worker exposure to these concentrations was for up to 4 h/day over an undefined period of days/years, but workers were not examined when these air concentrations were measured. Workers experienced chest tightness/congestion/ pain, sore throat, runny nose, nausea, vomiting, red eyeballs, tightness in the jaw and behind the ears, and hurting teeth only when spills or leaks occurred, at which time allylamine concentrations were not measured.