A Color Atlas of Comparative Pathology of Pulmonary by Franz Joel Leong, Veronique Dartois, Thomas Dick

By Franz Joel Leong, Veronique Dartois, Thomas Dick

An annual dying toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of recent medications, larger diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and instructing within the box of TB. It includes a hundred colour photos and illustrations that convey readability to the data provided. The atlas takes the weird procedure of masking a number of species histopathology, arguably the 1st and fairly in all likelihood the one source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal types. The editors have compiled details that is helping TB scientists to differentiate among the positive factors of all significant animal types on hand and to exploit them with their strengths and obstacles in brain. The e-book presents counsel for choosing the simplest animal model(s) to respond to particular questions and to check the efficacy of drug applicants.

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Extra resources for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

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Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nat Rev Drug Discov, 6, 29–40. , ed. 2006. Drug discovery and development: Technology in transition. Philadelphia: Churchill Livingstone Elsevier. , and Dick, T. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source dependant growth inhibitors deprived of in vivo efficacy. Nature Communications (submitted for review). , and Haag, H. 2006. High-throughput screening. In Drug discovery and development: Technology in transition, ed.

Even if the drugs do reach the bacilli, they do not affect the pathogen because it is in a nonsusceptible physiological state. , 2009). An Atlas for TB Drug Discovery Why is this atlas on comparative TB histopathology important for TB drug discovery? We do not know which lesion types are the most “difficult” to treat in human TB. What are the lesion types that are difficult to penetrate, which lesions contain phenotypically drug-resistant bacilli? What are the growth-terminating “culture conditions” in those lesions?

And Wu, L. 2009. Neglected disease research and development: How much are we really spending? PLoS Med, 6, e30. L. 2007. Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nat Rev Drug Discov, 6, 29–40. , ed. 2006. Drug discovery and development: Technology in transition. Philadelphia: Churchill Livingstone Elsevier. , and Dick, T. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source dependant growth inhibitors deprived of in vivo efficacy.

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